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elegans , PARP inhibition results in a significant lifespan extension in wild-type worms 190 , in a model of ataxia telangiectasia 135 and under hyperglycaemic conditions 221

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This means fat loss induced by AOD9604 may improve metabolic health beyond simple weight reduction, potentially improving insulin sensitivity and reducing inflammation even before significant weight loss occurs

Case reports and expert consensus instead highlight that tirzepatide alone achieves superior long-term weight loss (average 22 pounds at 21 weeks in STEP trials) without the tolerance decay that limits phentermine to 12 weeks of use
