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Antioxidants 11 (1), 170

FIGURE 1 Hormonal dysregulation is increasingly linked to both acute and chronic pain disorders, with sex hormones, such as estrogen, progesterone, and testosterone being important pain modulators (Blackburn-Munro and Blackburn-Munro, 2003)

GLP-1 receptors respond in parallel, amplifying insulin secretion, slowing gastric emptying, and sending satiety signals through the vagus nerve and into the brainstem

The introduction of FDA-approved pharmaceutical grade IGF-1 products in the form of Increlex and Iplex is likely to have seen an increase in rhIGF-1 abuse by athletes [97] and in the years that followed a number of newer IGF-1 compounds, analogues and products also became available, some even to the general public [98,99]

For the luciferase assays, 5 L of the supernatant was diluted with 95 L PBS (pH 7.4) in white flat-opaque-bottomed 96-well plates (Thermo Fisher Scientific)