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In addition, busulfan can interact with the glutathione and sulfhydryl groups and disrupt the cellular redox equilibrium, resulting in increased oxidative stress in cancer cells (36, 37)

This stress reduces the energy produced and stored in cells, causing damage and affecting their ability to work properly

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Supported by an increasing body of evidence, the ability of ADSC-EVs to promote chondrogenesis while decreasing cartilage lesions and inhibiting inflammation holds promise for the development of innovative regenerative therapies for cartilage-related disorders (Fig

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