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WoodruffPGKhashayarRLazarusSCJansonSAvilaPBousheyHAet al

BBB disruption is another strategy that will be discussed in more detail below

BMC Genomics, 12 , 112

Phytates are naturally occurring compounds found in plant-based foods like grains, legumes, and seeds that bind to zinc in the digestive tract, reducing its absorption and bioavailability

High levels of peripheral pro-inflammatory cytokines compromise the BBB integrity, cross over to the brain vicinity, and activate its resident immune cells, causing microglial activation, which in turn creates a medium of neuroinflammation [297]

Peptides tolerate this variability, but storing reconstituted vials in the door compartment