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HMGB1, a damage-associated molecular pattern (DAMP) protein, is known to interact with various receptors including RAGE, TLR2, TLR4, and TLR9, and can induce inflammatory responses (103105), C/EBP can be activated by inflammatory stimuli such as lipopolysaccharide (LPS), and it has been shown to upregulate the expression of IL-1, a cytokine that can be further enhanced by HMGB1 through its interaction with transcription factors like PU.1 (106109)

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