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The development of IC is attributed to several principal factors, including

notes that a significant number of people who are B12 deficient are unable to absorb the vitamin from food or supplements, and so need to inject it, which they can only do at their GP practice

This leads to a six-membered transition state involving two hydroxyl groups of Thr399 and Thr417 and one carbonyl group of Gln398

Low levels rise fast

Cell Death Differ 5(7):584-91, 1998
