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Diagnostic histochemistry in hepatic pathology

Effect of Re-Treatment With Gefitinib ('Iressa', ZD1839) After Acquisition of Resistance

indicates that the combination of both drugs, administered in low doses for 30 days to middle-aged men with impaired functional and structural characteristics of arterial walls, leads to an increase in the expression of Sirt1 (1.8 times), telomerase activity, the catalytic subunit of AMP 2 protein kinase (PRKAA) (1.5 times), and the KLOTHO gene (1.7 times) after just 30 days of treatment [132]

[DOI] [PubMed] [Google Scholar] 154.Liu H, Colavitti R, Rovira II, Finkel T

These alterations result from generation of highly reactive free radicals leading to peroxidation of membrane phospolypids rich in polyunsaturated fatty acids, particularly in conditions with increased intracellular iron and decreased antioxidant systems (namely glutathione) (Hirschhorn and Stockwell, 2019)