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Sanna F, Bonatesta RR, Frongia B, Uda S, Banni S, Melis MP, et al

We first elucidate the intricate pathophysiological mechanisms linking hyperuricemia, monosodium urate (MSU) crystal deposition, NLRP3 inflammasome activation, and chronic inflammation

Endogenous purines primarily originate from dead cells, and mitochondrial dysregulation leads to an accumulation of purines

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Among these, ceria nanoparticles (CeNPs) have emerged as a promising solution for addressing the long-standing challenges of drug delivery to the anterior segment of the eye