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doi: 10.1016/0022-3956(77)90009-7

Any cloudiness, particles, or discoloration indicates degradation

doi:10.1007/s12035-014-8648-2 Sheridan PA, Beck MA

5-amino-1-methylquinolinium injection also upregulates GLUT4 (glucose transporter 4) expression, promoting glucose transport into adipose and muscle cells and reducing blood glucose accumulation

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The core concept is that normal components of the tissue (or of the niche where the tumor grows) may provide, either occasionally or as part of a precise neoplastic strategy, a set of soluble factors that contribute to, or even determine, the growth of the tumor itself or facilitate immune evasion