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In a study also published in The New England Journal of Medicine a few months later in June 2021, those taking 5mg lost about 7.8kg (about 17lbs), those with 10mg lost 10.3kg (about 22.7lbs), and those on 15mg lost 12.4kg (about 27lbs)

But the bigger question is how you stop and what you do afterward

He considers it a potent biohack and a tool he may use again, but hes keen to see more scientific research

The SELECT trial enrolled a specific population - adults with pre-existing cardiovascular disease - so this finding applies directly to that population

But as the number of med spas offering these drugs grows, so do the concerns

December 2025 brought FDA approval for the oral version, designed for adults with obesity or overweight who also have at least one connected health issue
