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J Biol Chem 274:30093016 Ogiwara H, Takahashi K, Sasaki M, Kuroda T, Yoshida H, Watanabe R, Maruyama A, Makinoshima H, Chiwaki F, Sasaki H et al (2019) Targeting the vulnerability of glutathione metabolism in ARID1A-deficient cancers

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Alpha-Lipoic Acid Applications It is known that ALA affects carbohydrate and lipid metabolism [56,57], regulates appetite [58], fights complications of diabetic origin [59] and myocardial and cerebral reperfusion injuries [60], supports the therapy of neurodegenerative diseases [61], and activates apoptosis in tumor cell lines [62]

This combined treatment approach diminishes the severity of depressive symptoms and reduces their recurrence rate [66]

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Precise targeting of therapeutic genes or cells to the affected tissue is crucial but challenging