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chimeric constructs are provided that expand beyond targeted chemotherapy to immunotherapy by incorporating, for example, providing bispecific antibodies comprising an anti-ALPP/ALPPL2 antibody attached to a second antibody that is capable of recruiting and activating immune system components or attached to a moiety that is a checkpoint inhibitor e.g., anti- CTLA4 e.g., comprising an ipilimumab variable region), and/or antibodies directed against PD-L1 e.g., comprising an nivolumab, or pembrolizumab variable region), and/or antibodies directed against PD-L2

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Silencing ferritin expression via this method significantly enhanced the sensitivity of tumor cells to the DNA-alkylating agent carmustine (BCNU), a chemotherapeutic commonly used in glioma treatment [151]