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UPS and autophagy interact in the pathogenesis of DKD, focal segmental glomerulosclerosis (FSGS), and ccRCC, and jointly regulate disease progression
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GIP also activates an anti-nausea circuit in the brainstem, which helps offset some of the gastrointestinal burden created by GLP-1. GLP-1R: appetite, tolerability, and heart rate The GLP-1 arm carries appetite suppression, slower stomach emptying, most nausea, and part of the heart-rate signal