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2021;54:164175 e166

D.ShawD

We also observed a significant preservation of corpus callosum width (axonal myelination), a significant decrease in degenerating neurons, a reduction in Iba1 (microglial marker), decreased lipid peroxidation, and preservation of brainderived neurotrophic factor (BDNF) in the brains of Immunocal-pretreated mice compared to untreated TBI mice

[PubMed ID: 36460123]

Clinical translation requires human CSF pharmacokinetic assays to prove BBB bypass, a rigorous dose-escalation Phase I trial to establish a safe human NOAEL for chronic dosing, and an RCT utilizing precise neurocognitive testing (e.g., MoCA) to confirm that murine transcriptomic shifts yield functional neuroprotection in humans

Possible side effects include: Redness Itching Tingling Dryness Peeling Mild stinging Breakouts or small bumps Bruising or pain with injectable use Allergy-type reactions such as hives or swelling Stop using the product and seek medical care if you notice hives, swelling, trouble breathing, severe irritation, or symptoms that feel unusual for you