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While aldose reductase contributes to MG metabolism, the glyoxalase system is expected to be the primary route in most human tissues under normal conditions, except for the renal medulla, which has unusually high levels of aldose reductase [83]

Selenium deficiency and Se toxicity (selenosis) can result in significant health problems [100]

runtime: 0.510 minutes

A balance between the ERK and AKT pathways may determine the cell fate towards survival or apoptosis

Expert Clinical Visual Grading: An independent trained evaluator assessed hyperpigmentation severity and skin tone evenness under standardised conditions at both timepoints, using a validated PCR clinical grading scale