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The solution to this problem, which is widely recognized, is the generation of small molecule, blood-brain-barrier (BBB) permeable drugs that act as mimetics of pertinent neurotrophic factors

doi: 10.5812/jssc.65815

MMPs (such as MMP-1, -2, -3, -7, -9, -13, 14, and ADAMTS-4) are upregulated in IDD and correlate with the severity of degeneration (Huang YC

Jack CI, Calverley PM, Donnelly RJ, et al

When growth hormone then interacts with these upregulated receptors, it produces a dose-dependent and time-dependent increase in cell proliferation

July 26, 2023
