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Moreover, in STN-DBS PD samples, expression of an angiogenic factor, vascular endothelial growth factor (VEGF), was significantly upregulated compared to the other groups

Glycemic Control with Diet, Sulfonylurea, Metformin, or Insulin in Patients with Type 2 Diabetes Mellitus: Progressive Requirement for Multiple Therapies (UKPDS 49)
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This process not only benefits to maintain the reducing environment within cells but also regenerates other crucial antioxidants like vitamin C and vitamin E, thereby boosting the cells antioxidant ability (Poladian et al., 2023)

doi:10.1016/j.clinph.2014.12.021 Oghalai JS, Manolidis S, Barth JL, Stewart MG, Jenkins HA

These results confirm that VacA disrupts TRPML1 activity and causes disruption of lysosomal calcium homeostasis
