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The most extensively documented involves upregulation of vascular endothelial growth factor (VEGF) and its receptor VEGFR2, promoting angiogenesis, the formation of new blood vessels, in injured tissue

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It gains its effectiveness from both its ability to bind with copper and its ability to up and down-regulate a minimum of 4,000 different genes

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Gab1 in the Gab family of docking proteins which can directly or indirectly bind to c-Met through Grb2, is the most critical downstream multi-adapter protein of c-Met (Birchmeier et al., 1997

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