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Cellular and animal models using environmental and biological toxins, especially lipopolysaccharides (LPS), herbicides and pesticides like rotenone or MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), can induce both astrogliosis and microgliosis, which is accompanied by neuronal death, mitochondrial dysfunction and nuclear fragmentation [41-45]

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Although this definition has been widely used for over two decades, the definition of oxidative stress will likely evolve and undergo modification in the future

Zhang S, Zhang S, Wang H, Chen Y

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