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Approximately 900 adult participants were enrolled across six randomized, double-blind, placebo-controlled clinical trials conducted between 2001 and 2006

Science 335 , 15031506 (2012)

Both paracellular hyperpermeability [demonstrated by abnormal TJ expression and upregulation of myosin light chain kinase (MLCK) activity (86, 322324)] and transcellular hyperpermeability [represented by bacterial internalization to epithelia (325)] were documented in mucosal biopsies of patients with Crohn's disease and UC

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