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Vitamin B12 is necessary for patients with a low serum level of vitamin B12 because they take particular medications or because they suffer from pernicious anemia, gastrointestinal or autoimmune disorders, or alcoholism

2 Pathological mechanisms of heat stress-induced sperm damage 2.1 Spermatogenic microenvironment disruption and resultant failure Spermatogenesis in mammals constitutes a highly intricate and precisely orchestrated process of cellular differentiation, the fidelity of which depends upon the stability of the testicular spermatogenic microenvironment

Insulin activates the PI3K/Akt signaling pathway, which regulates autophagy, inflammation, and oxidative stress in ovarian granulosa cells, thereby promoting follicular development and improving ovarian dysfunction 331,332,333,334,335

10.1016/j.clim.2006.08.009 Clin Immunol (Orlando, Fla)

[DOI] [PubMed] [Google Scholar] 13.Hou D., Li F