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First, the gut microbiota could regulate metabolic processes in the human body through gut microbial metabolites as short-chain fatty acids, trimethylamine N-oxide, and bile acids, all of which have been associated with many CAD-related phenotype and can influence the course of cardiovascular disease (Wang and Zhao, 2018)

Formenti A, Arrigoni E, Sansone V, et al

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In terms of plasticity, IL-1 and can downregulate the expression of MITF and melanocytic antigens, favoring melanoma dedifferentiation and phenotype switching (171)

Lng and Nguyn, 2013)