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Acknowledgements This work was supported by AIRCAssociazione Italiana per la Ricerca sul Cancro (grants 22910), Ministero dellUniversit e della Ricerca (PRIN 2022 grant, 2022 HREZJT, PRIN 2022 grant P2022BR3SP, PNRR D3 4 Health, Fondo Italiano per la Ricerca applicata-2022, grant 01017), Regione Piemonte (FESR 2021-2027, grant SWIch, project IPeR), FPRC 5xmille Ministero Salute 2020 - PRO-ACTIVE, FPRC 51000 Ministero della Salute 2022 CARESS, Ricerca Corrente 2025