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In vitro, uric acid is a powerful scavenger of ROS32 and by being preferentially oxidized as a substrate for oxidation by haem protein or H2O2 systems, it can protect against oxidative damage.33 As marker of oxidative stress, the GSH/GSSG ratio was determined in both duodenal and sigmoid biopsies

References Oh R, Brown DL

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The Mendelian disorders of the epigenetic machinery

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