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This mechanistic link explains why oxidative stress can amplify SASP-mediated tissue damage, creating a self-reinforcing cycle of inflammation and cellular dysfunction.18 Senolytics reduce SASP not only by eliminating the senescent cells that produce high ROS but also by disrupting pro-survival signaling pathways that sustain SASP activity

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Although myelin may be seen in some invertebrates such as crustaceans, the vertebrate CNS myelin is a sui generis phenomenon among animals as its morphology and cell origin are unique to that clade ( The particularities of myelination in CNS are not restricted to myelin itself, though

doi: 10.3322/caac.20038 23 ChangJ