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St Johns wort: effect on CYP2D6 activity using dextromethorphan-dextrorphan ratios
PDQ Melanoma Treatment

[16] [18] There is insufficient evidence to determine the risk of adverse outcomes in human pregnancies, and thus, use during pregnancy should be guided by clinical judgment and individual risk assessment

& Ye, P

A patient may need a topical cream when only oral capsules are available in the needed hormone, or a sublingual preparation when they cannot tolerate oral delivery
New Medicine 2015;19:901
