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While this route requires the peptide to cross the blood-brain barrier to reach CNS targets, the BBB is actually compromised in active MS lesions, which paradoxically may improve drug penetration at the sites where treatment is most needed

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Certain peptides demonstrate good tolerability in short-term studies, and the long-term effects on fertility and pregnancy warrant further clinical research

That is what their reference to "immunogenicity" means

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Best Peptides for Tissue Repair and Recovery Research A ranked overview of six peptides that recur most in the published tissue-repair and recovery literature