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The peptide's anti-inflammatory effects complement its synaptogenic properties, as chronic neuroinflammation actively disrupts synaptic function and prevents formation of new synapses

NADPH solution was added to the plates, and the absorbance was measured at 412 nm using a CLARIOstar microplate reader (CLARIOstar, BMG LABTECH, Germany)

Peptides modulate targeted biological pathways

Multiple studies have shown that the Notch and transforming growth factor-1 (TGF-1)/Smad3 pathways could trigger epithelial-mesenchymal transition (EMT) and extracellular matrix (ECM) accumulation, leading to renal interstitial fibrosis (85)

BBB dysfunction in these pathologies may result in compromised transport and permeability properties of the barrier as well as in alterations in cerebrovascular regulatory mechanisms of blood flow, with ensuing perturbed signalling between brain endothelium and associated cells, such as glia and neurons

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