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[DOI] [PubMed] [Google Scholar] 20.Dittgen T., Pitzer C., Plaas C., Kirsch F., Vogt G., Laage R., Schneider A

Handb Clin Neurol 120:891914 Chen D et al (2022) Serum vitamin levels in multiple system atrophy: a case-control study

Most trials used 3-5g/day

Epidermal growth factor (EGF) and EGF receptor (EGFR) EGF is a mediator with crucial roles in the proliferation, survival, differentiation, and migration of vascular endothelial cells, through EGFR binding

Environmental factors like UV exposure or pollution accelerate this by inducing more DNA damage, thus more PARP activity
