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Santonastaso M, Mottola F, Iovine C, Colacurci N, Rocco L

10.1098/rstb.2009.0294 44

Some scholars found that after being treated with Salvianolic Acid B, the degree of atrial fibrosis was significantly reduced, its mechanism may relate to that Salvianolic Acid B can reduce the stimulating effects of Ang II on the accumulation of extracellular matrix via miR-148a-3p induction by activating AMP-activated protein kinase (AMPK)/forkhead box proteins O1 (FOXO1) pathway (29)

Moreover, positron emission tomography (PET) studies demonstrate enhanced activation of microglia in the brainstem, basal ganglia, and frontotemporal cortical regions during early PD stages 56,57

575 Microvesicles (501000 nm) sprout outward directly from the plasma membrane, and apoptotic bodies (10005000 nm) are released by cells undergoing apoptosis through membrane foaming and rupture

Therefore, the primary candidate for FRDA clinical translation became deferiprone (DFP), a small, lipophilic bidentate chelator capable of crossing cellular and mitochondrial membranes to access and theoretically redistribute the toxic accumulation of mitochondrial iron to extracellular sinks [117,118]