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Tier 3 (Promising but early): Some human evidence, but outcomes are inconsistent or limited

The genetic manipulation used in the study produced a striatum-wide increase in the D1/D2 receptor ratio from early ages, which has clinical validity given the findings of low D2 receptor availability 51,52,53 and no changes to D1Rs in AUD positive individuals across the striatum 54 , suggesting that D1/D2 receptor ratio might also differ among humans with a history of alcohol abuse

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Funding The authors declare that no funds or grants were received during the preparation of this manuscript

Fatigue is usually the first red flag