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In Australia, these drugs are popular for managing obesity and diabetes, but knowing the contraindications helps ensure they're used appropriately

The FDA does not approve compounded versions of semaglutide or tirzepatide and has issued warnings about them in 2026

PCOS is a hormonal and metabolic disorder that occurs in women of reproductive age and is associated with high androgen levels and insulin resistance

In addition to the well-known effects of GLP-1 and GLP-1 RA in improving insulin sensitivity and reducing body weight, at central levels, GLP-1 and GLP-1 RA might exert regulating effects on GhRH release, and on concomitant gonadotropin secretion, likely by activating the kisspeptin hypothalamic system, a key regulator of the pulsatile release of GnRH from GnRH neurons

[DOI] [PubMed] [Google Scholar] 521.Hay C.W., Sinclair E.M., Bermano G., Durward E., Tadayyon M., Docherty K

Semaglutide also works by slowing down movement of food through the stomach and curbing appetite, thereby causing weight loss