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DRP-104 is a prodrug of DON that is currently undergoing clinical trials (NCT04471415)

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Stanley et al., 2011)

Although more studies are necessary to determine the exact functions of claudins in TJs, animal studies have indicated the importance of claudins in the integrity of TJs

A subsequent study also supported the hypothesis that the Asn-43 residue in the canonical tetrahedral metal-binding site in SLC30A10 is important for Mn transport and further demonstrated that residue 43 is a key position in the protein that mediates the inward transmembrane calcium gradient for Mn exchange when expressed in HEK293T cells 90