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doi: 10.3389/fphar.2025.1621030 Summary Keywords epigenetic modifications, macrophage polarization, metabolic reprogramming, pulmonary arterial hypertension, pulmonary vascular remodeling, therapeutic targets Citation Xu W, Shen Y, Wan Z and Guo J (2025) Macrophage-driven immunopathology in pulmonary arterial hypertension: from mechanisms to targeted therapies