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Despite these kinetic and quantitative differences, both models converge on a conserved DAM transcriptional core defined by upregulation of canonical DAM genes and coordinated downregulation of homeostatic microglial programs

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a specific increase of fibroblast-specific GPX3 expression or a spatial shift from apically secreted soluble GPX3 to interstitial matrix-associated GPX3, reminiscent of what has been observed in a mouse model of influenza pneumonia 33

Its role is more about converting food into energy

Further studies should seek to clarify whether recruited proteins such as PDIA3, CNX and BiP are co-localized in condensates within the ER or just in the ER or ER-derived vesicles as a whole, thereby helping to elucidate the detailed mechanism of protein quality control granules in the ER

(These statements have not been evaluated by the Food and Drug Administration