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Elevated NNMT gene expression is notably observed in the liver and white adipose tissue (WAT) of individuals with diabetic mice, obesity, and rats afflicted with MetS

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(Wang et al., 2021) found that XIST and HOTAIR are long non-coding RNAs (lncRNAs) with significantly elevated expression in the serum of patients with osteoporosis, and that XIST and HOTAIR acted as ceRNAs (competing endogenous RNAs) to upregulate NNMT expression by adsorbing miR-29b-respectively

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