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evaluated the plasma L-carnitine levels of subjects with high levels of TMAO ( n = 2,595) and found that the intake of large amounts of L-carnitine caused cardiovascular disease (CVD) and major adverse cardiac events (MI, stroke, or death)
The final step of production occurs in the liver, where enzymes oxidize TMA into TMAO

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The lipids will form a greasy or translucent spot due to their greasy texture, and penetrate the filter paper