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Description
Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction

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The deltoid (upper arm) is also an IM site but can be harder to reach on your own

(figure 6)

Following digestion, the lung tissue was minced using a scalpel blade, and the resulting tissue/cell suspension was filtered twice through a 70 m strainer while grinding

At 0.5mm, a stamped microneedle traverses the stratum corneum (typically 10 to 30 microns), passes through the viable epidermis (50 to 100 microns), and lands in the upper papillary dermis (which begins around 100 to 150 microns deep)
