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657 The BBB is composed of tightly packed, non-fenestrated endothelial cells linked by TJs and adherens junctions (AJs), which share a common basement membrane with pericytes and astrocytes

GPx6 is a human selenoprotein [131]

Active site residues U46, K48, Q81, and W136 are highlighted and shown as sticks

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The extract demonstrated a favorable safety profile, characterized by the absence of significant adverse events or laboratory abnormalities

However, despite over two decades of investigation elucidating their complex biological functions in disease progression, DAMP-targeted therapies remain in the early translational phase