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Moreover, CDK4/6 inhibition-induced senescence may contribute to innate immune activation, as senescent cells secrete chemokines (e.g., CCL2 and CXCL10) that recruit and activate NK cells [88]

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Fibroblasts derived from these CIPO-LIG3 patients exhibit multiple hallmarks of mitochondrial impairment: abnormal cristae and swollen mitochondria with increased average area, as observed with transmission electron microscopy, as well as reduced uncoupled oxygen consumption and decreased ATP levels

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Z13 beads were washed with TBS containing 50 mM octyl-thio-glucoside and bead-bound materials were then eluted with TBS/octyl-thio-glucoside buffer containing z13 peptide (1 mg ml 1 )