melanotic macules definition macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in Labial or Oral Melanotic Macule
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elegans transforming growth factor- family) is dependent on DAF-16, suggesting that the transforming growth factor- pathway is an upstream regulator of IIS-mediated longevity

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