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This may relate to immune system changes, medication effects, or altered skin barrier function with aging

(2020) Micronutrients in support to the one carbon cycle for the modulation of blood fasting homocysteine in PCOS women

We see a functional iron deficiency when there is reduced heme synthesis or inhibition of heme synthesis either because hemoglobin production is being inhibited or is defective or iron is not being released in sufficient amounts to support hemoglobin production

This way, the body gets the B12 it needs without any absorption problems

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Antonopoulou E, Kentepozidou E, Feidantsis K, Roufidou C, Despoti S, Chatzifotis S