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In a systematic review with meta-analysis that aimed to synthesize the existing knowledge between antioxidants and the pulmonary function of individuals with CF, the authors recommended the administration of NAC (primarily by inhalation) as an adjunct to treatment, as it became evident that oral supplementation of NAC exhibited beneficial effects in preventing deterioration of lung function, but not significantly

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the clinical evaluation of cases after treatment revealed a very good to excellent response on right side versus almost poor results on the left side
