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Tesamorelin is an FDA-approved synthetic GHRH analog used to reduce visceral fat in HIV-associated lipodystrophy and reliably increases GH and insulin growth factor 1 (IGF-1)

or (b) rely on functional status items not collected in all settings (for instance, the Discharge Mobility and Self-Care Score measures rely on items not collected in LTCHs)

The ice crystal formation physically damages the peptide structure, and this damage does not reverse when the solution thaws