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Treatment of H9C2 cells with palmitate significantly increased ROS and redox imbalance, curcumin activated the NRF2 signaling cascade, thereby significantly increasing the expression of downstream genes glutamate-cysteine ligase catalytic (Gclc), HO-1, and NAD(P)H quinone oxidoreductase 1 (NQO-1), and antioxidant response inhibited myocardial fibrosis (Zeng et al., 2015)

[ 344 ] A study in bioinformatics revealed that 9 crucial genes (CXCL9, TIMP1, PTGS2, ICAM1, CXCL1, MMP9, IL1B, CXCL8, and IL6) are linked to the Mayo score in ulcerative colitis, with BACH1 serving as a vital transcription factor regulating their expression

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Additionally, Spirulina maxima cultured in deep-sea water enhanced TRAIL-induced apoptosis over seawater-grown strains, which was linked to higher -carotene and ascorbic acid levels [84]

Acknowledgments There was no financial support for this work