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More importantly, exercise-based therapy to reduce body weight for the treatment of KOA is consistently recommended in treatment guidelines [9]

Moreover, participants were asked not to change routine dietary and physical activity habits during the study to eliminate the probable confounding impacts of dietary/physical activity alterations on the study results, as well as not to use pro/pre/synbiotic-supplemented food products during the intervention period

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The normal function of the immune system

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Participants were randomly assigned to consume red meat (highest L-carnitine containing diet), white meat, and non-meat (lowest L-carnitine containing diet) diets in one of six orders, with a washout period of at least two weeks between each diet intervention, as described under Methods