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Patients with severe renal impairment, myasthenia gravis, or heart block should avoid magnesium supplementation, and regular monitoring is required for those with kidney disease

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Hepatoma Res 4:39 Gao T, Wang T, Wang Z, Cao J, Dong Y, Chen Y (2021) Melatonin-mediated MT2 attenuates colitis induced by dextran sodium sulfate via PI3K/AKT/Nrf2/SIRT1/ROR/NF-B signaling pathways

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However, some studies highlighted the potential ability of BBR to prevent oxidative stress-induced senescence by activating AMPK and restoring NAD + levels (Song et al., 2020)