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Emerging role of one-carbon metabolism and DNA methylation enrichment on -containing GABAA receptor expression in the cerebellum of subjects with alcohol use disorders (AUD)

post-dose, P c = p-value for change from baseline to end of study at pre-dose, P e = p-value end of study at pre-dose comparing placebo vs

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Abbreviations used BBB blood brain barrier BBBD blood brain barrier disruption EAAC1 excitatory amino acid carrier type 1 GFAP glial fibrillary acidic protein GSH reduced glutathione GSSG oxidized glutathione HPLC-ECD high performance liquid chromatography with electrochemical detection Iba1 ionized calcium binding adaptor molecule 1 ICAL Immunocal MRI magnetic resonance imaging PBS-T phosphate-buffered saline with 0.1% Triton X-100 PHF paired helical filament PVDF polyvinylidene difluoride SDS-PAGE sodium dodecylsulfate polyacrylamide gel electrophoresis TBI traumatic brain injury Footnotes Conflicts of Interest The authors have received funding from Immunotec Inc

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The pharmacological properties of this herb are primarily ascribed to a diverse range of bioactive constituents, which include phenylpropanoids (such as rosavin, rosarin, and rosin), salidroside, tyrosol, flavonoids, tannins, and essential oils ( 5.2 Mechanisms of action The antidepressant properties of Rhodiola rosea are characterized by a multi-faceted mechanism of action, indicative of its extensive phytochemical composition (Figure 1)