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Lung-intestinal axis, shuangshen granules attenuate lung metastasis by regulating the intestinal microbiota and related metabolites

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The ability of PEITC to alter the expression and activity of CYP enzymes has been generally associated with a protective effect against (pro)carcinogen-induced tumor development in animal experiments (reviewed in 24)

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The electrophilic modification of reactive cysteine residues on Keap1 is one of the most well-documented mechanisms: electrophilic phytochemicals like sulforaphane react with sensor cysteines (i.e., Cys151 and others) to inhibit ubiquitination of Nrf2 mediated by Keap1 and increase its half-life and nuclear localization [84, 90, 377]

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, Laitila A., and Ouwehand A

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Despite this vulnerability, lung tumors are frequently characterized by resistance to ferroptosis, partly due to their constant exposure to high oxygen levels

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Targeting regulated cell death in tumor nanomedicines

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