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Gray Hair Syndromes (GHSs), including Griscelli, Chediak-Higashi, Elejalde, and Cross syndromes, are rare autosomal recessive conditions characterized by silvery gray hair and severe multisystem impairments

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2,100 For instance, elevated levels of copper in the tumor tissue and serum have been observed in patients with oral, 101 thyroid, 102 breast, 103,104 lung, 105,106 pancreatic, 107 gallbladder, 108 colorectal, 109 prostate, 110 and gynecological cancers, 111 and are significantly associated with poor prognostic outcomes